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The majority of malignancies showed weak to moderate cytoplasmic positivity. Membranous positivity was observed in colorectal and gastric cancers while nuclear positivity was observed in testicular, ovarian and cervical cancers. Malignant carcinoids, melanomas, renal and skin cancers were mainly negative.
GENE INFORMATION
Gene name
BRWD3 (HGNC Symbol)
Synonyms
FLJ38568, MRX93
Description
Bromodomain and WD repeat domain containing 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene cause mental retardation X-linked type 93, which is also referred to as mental retardation X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. [provided by RefSeq, May 2010]