Expression of CLDN2 in cancer - Summary - The Human Protein Atlas

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CLDN2

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TISSUE

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CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Claudin 2

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB002609

GENE INFORMATION
Gene name	CLDN2
Synonyms
Description	Claudin 2 (HGNC Symbol)
Entrez gene summary	This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	106900164 - 106930861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165376 (version 83.38)
Entrez gene	9075
UniProt	P57739 (UniProt - Evidence at protein level)
neXtProt	NX_P57739
Antibodypedia	CLDN2 antibodies

PROTEIN BROWSER

CLDN2-001	CLDN2-201	CLDN2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN2-001 ENSP00000336571 ENST00000336803	P57739 [Direct mapping] Claudin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0070062 [extracellular exosome] Show all	230 aa 24.5 kDa	No	4
CLDN2-201 ENSP00000443230 ENST00000540876	P57739 [Direct mapping] Claudin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0070062 [extracellular exosome] Show all	230 aa 24.5 kDa	No	4
CLDN2-202 ENSP00000441283 ENST00000541806	P57739 [Direct mapping] Claudin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0070062 [extracellular exosome] Show all	230 aa 24.5 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.