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WRN

CANCER ATLAS

Gene description

 Werner syndrome, RecQ helicase-like

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028661

GENE INFORMATION

Gene name

 WRN (HGNC Symbol)

Synonyms

 RECQ3, RECQL2

Description

 Werner syndrome, RecQ helicase-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p12

Chromosome location (bp)

 31033801 - 31173769

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165392 (version 83.38)

Entrez gene

 7486

UniProt

 Q14191 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14191

Antibodypedia

 WRN antibodies

PROTEIN BROWSER
WRN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WRN-001
ENSP00000298139
ENST00000298139
Q14191 [Direct mapping]
Werner syndrome ATP-dependent helicase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0000403 [Y-form DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0001302 [replicative cell aging]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003824 [catalytic activity]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005813 [centrosome]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007420 [brain development]
GO:0007568 [aging]
GO:0007569 [cell aging]
GO:0008026 [ATP-dependent helicase activity]
GO:0008408 [3'-5' exonuclease activity]
GO:0009267 [cellular response to starvation]
GO:0009378 [four-way junction helicase activity]
GO:0010225 [response to UV-C]
GO:0010259 [multicellular organismal aging]
GO:0016887 [ATPase activity]
GO:0016925 [protein sumoylation]
GO:0030145 [manganese ion binding]
GO:0031297 [replication fork processing]
GO:0032066 [nucleolus to nucleoplasm transport]
GO:0032389 [MutLalpha complex]
GO:0032403 [protein complex binding]
GO:0032508 [DNA duplex unwinding]
GO:0040009 [regulation of growth rate]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043138 [3'-5' DNA helicase activity]
GO:0043140 [ATP-dependent 3'-5' DNA helicase activity]
GO:0043687 [post-translational protein modification]
GO:0044237 [cellular metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051880 [G-quadruplex DNA binding]
GO:0071480 [cellular response to gamma radiation]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 1432 aa
162.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.