Expression of MARCH8 in cancer - Summary

CANCER ATLAS

Gene description

Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014597

GENE INFORMATION
Gene name	MARCH8 (HGNC Symbol)
Synonyms	c-MIR, CMIR, MARCH-VIII, MIR, RNF178
Description	Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Chromosome	10
Cytoband
Chromosome location (bp)	45454585 - 45594906
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165406 (version 83.38)
Entrez gene	220972
UniProt	Q5T0T0 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T0T0
Antibodypedia	MARCH8 antibodies

PROTEIN BROWSER

MARCH8-001	MARCH8-002	MARCH8-004	MARCH8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH8-001 ENSP00000379116 ENST00000395769	Q5T0T0 [Direct mapping] E3 ubiquitin-protein ligase MARCH8 A0A024R7U2 [Target identity:100%; Query identity:100%] Membrane-associated ring finger (C3HC4) 8, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000209 [protein polyubiquitination] GO:0002250 [adaptive immune response] GO:0004842 [ubiquitin-protein transferase activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] Show all	291 aa 33 kDa	No	2
MARCH8-002 ENSP00000411848 ENST00000453424	Q5T0T0 [Direct mapping] E3 ubiquitin-protein ligase MARCH8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000209 [protein polyubiquitination] GO:0002250 [adaptive immune response] GO:0002495 [antigen processing and presentation of peptide antigen via MHC class II] GO:0004842 [ubiquitin-protein transferase activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042289 [MHC class II protein binding] GO:0045347 [negative regulation of MHC class II biosynthetic process] GO:0061630 [ubiquitin protein ligase activity] Show all	573 aa 63.3 kDa	No	2
MARCH8-004 ENSP00000396678 ENST00000453980	A0A0A0MSM7 [Direct mapping] E3 ubiquitin-protein ligase MARCH8 Show all	Predicted intracellular proteins Show all		89 aa 9.7 kDa	No	0
MARCH8-201 ENSP00000317087 ENST00000319836	Q5T0T0 [Direct mapping] E3 ubiquitin-protein ligase MARCH8 A0A024R7U2 [Target identity:100%; Query identity:100%] Membrane-associated ring finger (C3HC4) 8, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000209 [protein polyubiquitination] GO:0002250 [adaptive immune response] GO:0004842 [ubiquitin-protein transferase activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] Show all	291 aa 33 kDa	No	2