Expression of CFL2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cofilin 2 (muscle)

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA045599

GENE INFORMATION
Gene name	CFL2 (HGNC Symbol)
Synonyms	NEM7
Description	Cofilin 2 (muscle) (HGNC Symbol)
Entrez gene summary	This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Chromosome	14
Cytoband	q13.1
Chromosome location (bp)	34706769 - 34714823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165410 (version 83.38)
Entrez gene	1073
UniProt	Q9Y281 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y281
Antibodypedia	CFL2 antibodies

PROTEIN BROWSER

CFL2-001	CFL2-002	CFL2-005	CFL2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFL2-001 ENSP00000298159 ENST00000298159	Q9Y281 [Direct mapping] Cofilin-2 Q549N0 [Target identity:100%; Query identity:100%] Cofilin 2 (Muscle), isoform CRA_a; Cofilin 2 (Muscle), isoform CRA_c; Cofilin isoform; cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNA Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007015 [actin filament organization] GO:0015629 [actin cytoskeleton] GO:0016363 [nuclear matrix] GO:0030042 [actin filament depolymerization] GO:0030836 [positive regulation of actin filament depolymerization] GO:0031674 [I band] GO:0045214 [sarcomere organization] GO:0046716 [muscle cell cellular homeostasis] GO:0070062 [extracellular exosome] Show all	166 aa 18.7 kDa	No	0
CFL2-002 ENSP00000340635 ENST00000341223	Q9Y281 [Direct mapping] Cofilin-2 Q549N0 [Target identity:100%; Query identity:100%] Cofilin 2 (Muscle), isoform CRA_a; Cofilin 2 (Muscle), isoform CRA_c; Cofilin isoform; cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNA Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0015629 [actin cytoskeleton] GO:0016363 [nuclear matrix] GO:0030836 [positive regulation of actin filament depolymerization] GO:0031674 [I band] GO:0070062 [extracellular exosome] Show all	166 aa 18.7 kDa	No	0
CFL2-005 ENSP00000452451 ENST00000555765	Q9Y281 [Direct mapping] Cofilin-2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0015629 [actin cytoskeleton] GO:0016363 [nuclear matrix] GO:0030836 [positive regulation of actin filament depolymerization] GO:0031674 [I band] GO:0070062 [extracellular exosome] Show all	149 aa 16.9 kDa	No	0
CFL2-006 ENSP00000452188 ENST00000556161	Q9Y281 [Direct mapping] Cofilin-2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0015629 [actin cytoskeleton] GO:0016363 [nuclear matrix] GO:0030836 [positive regulation of actin filament depolymerization] GO:0031674 [I band] GO:0070062 [extracellular exosome] Show all	149 aa 16.9 kDa	No	0