Cell atlas - FOLR2 - The Human Protein Atlas

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FOLR2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FOLR2
Gene description	Folate receptor 2 (fetal)
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (U-698, Daudi)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-698, Daudi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FOLR2
Synonyms
Description	Folate receptor 2 (fetal) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	72216601 - 72221950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165457 (version 83.38)
Entrez gene	2350
UniProt	P14207 (UniProt - Evidence at protein level)
neXtProt	NX_P14207
Antibodypedia	FOLR2 antibodies

PROTEIN BROWSER

FOLR2-001	FOLR2-002	FOLR2-003	FOLR2-004	FOLR2-005	FOLR2-006	FOLR2-007	FOLR2-008	FOLR2-009	FOLR2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOLR2-001 ENSP00000298223 ENST00000298223	P14207 [Direct mapping] Folate receptor beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005542 [folic acid binding] GO:0005576 [extracellular region] GO:0006898 [receptor-mediated endocytosis] GO:0006954 [inflammatory response] GO:0008144 [drug binding] GO:0008284 [positive regulation of cell proliferation] GO:0008517 [folic acid transporter activity] GO:0009986 [cell surface] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0031362 [anchored component of external side of plasma membrane] GO:0050758 [regulation of thymidylate synthase biosynthetic process] GO:0051870 [methotrexate binding] GO:0061714 [folic acid receptor activity] GO:0071231 [cellular response to folic acid] Show all	255 aa 29.3 kDa	Yes	1
FOLR2-002 ENSP00000441547 ENST00000539412	F5GZ45 [Direct mapping] Folate receptor beta Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 21.1 kDa	Yes	0
FOLR2-003 ENSP00000438568 ENST00000536778	F5H3Z4 [Direct mapping] Folate receptor beta Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 23 kDa	Yes	0
FOLR2-004 ENSP00000444794 ENST00000535625	F5H4Z6 [Direct mapping] Folate receptor beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 20 kDa	Yes	0
FOLR2-005 ENSP00000321957 ENST00000321324	E7EU04 [Direct mapping] Folate receptor beta Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		210 aa 24.4 kDa	Yes	0
FOLR2-006 ENSP00000443307 ENST00000541003	F5H5L8 [Direct mapping] Folate receptor beta Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 16.9 kDa	No	0
FOLR2-007 ENSP00000405638 ENST00000449475	J3KQP4 [Direct mapping] Folate receptor beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		251 aa 28.9 kDa	Yes	1
FOLR2-008 ENSP00000414094 ENST00000454954	J3KR13 [Direct mapping] Folate receptor beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		214 aa 24.5 kDa	No	1
FOLR2-009 ENSP00000440337 ENST00000538353	F5GXV3 [Direct mapping] Folate receptor beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 19.9 kDa	Yes	0
FOLR2-201 ENSP00000480592 ENST00000619261	A0A087WWY2 [Direct mapping] Folate receptor beta Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		244 aa 26.2 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.