Expression of CRYL1 in cancer - Summary

CANCER ATLAS

Gene description

Crystallin, lambda 1

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040403

GENE INFORMATION
Gene name	CRYL1 (HGNC Symbol)
Synonyms	GDH, lambda-CRY, MGC149525, MGC149526
Description	Crystallin, lambda 1 (HGNC Symbol)
Entrez gene summary	The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	20403667 - 20525857
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165475 (version 83.38)
Entrez gene	51084
UniProt	Q9Y2S2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2S2
Antibodypedia	CRYL1 antibodies

PROTEIN BROWSER

CRYL1-001	CRYL1-002	CRYL1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYL1-001 ENSP00000298248 ENST00000298248	Q9Y2S2 [Direct mapping] Lambda-crystallin homolog V9HWG2 [Target identity:100%; Query identity:100%] Epididymis luminal protein 30 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0050104 [L-gulonate 3-dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	319 aa 35.4 kDa	No	0
CRYL1-002 ENSP00000372262 ENST00000382812	Q9Y2S2 [Direct mapping] Lambda-crystallin homolog A0A024RDM2 [Target identity:100%; Query identity:100%] Crystallin, lambda 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0050104 [L-gulonate 3-dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	297 aa 33.4 kDa	No	0
CRYL1-003 ENSP00000479908 ENST00000480748	A0A087WW38 [Direct mapping] Lambda-crystallin homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0006631 [fatty acid metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	148 aa 16.2 kDa	No	0