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Weak to moderate cytoplasmic immunoreactivity was observed in most cancer tissues. Most thyroid cancers were strongly stained. Gliomas along with several lymphomas, renal, lung and urothelial cancers were negative.
GENE INFORMATION
Gene name
LRR1 (HGNC Symbol)
Synonyms
LRR-1, MGC20689, PPIL5
Description
Leucine rich repeat protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
