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NGB

GENERAL INFORMATION

Gene name

 NGB

Gene description

 Neuroglobin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (adrenal gland, cerebral cortex, fallopian tube)
GTEx:Group enriched (hypothalamus, cerebral cortex, pituitary gland)
FANTOM5:Tissue enhanced (brain)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in adrenal gland and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042615 , HPA058596
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebral cortex, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hypothalamus, cerebral cortex, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain)

GENE INFORMATION

Gene name

 NGB

Synonyms

Description

 Neuroglobin (HGNC Symbol)

Entrez gene summary

 This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 77265483 - 77271312

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165553 (version 83.38)

Entrez gene

 58157

UniProt

 Q9NPG2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPG2

Antibodypedia

 NGB antibodies

PROTEIN BROWSER
NGB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NGB-001
ENSP00000298352
ENST00000298352
Q9NPG2 [Direct mapping]
Neuroglobin
A0M8W9 [Target identity:100%; Query identity:100%]
Neuroglobin; Neuroglobin, isoform CRA_a; cDNA, FLJ96443, Homo sapiens neuroglobin (NGB), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005344 [oxygen transporter activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006915 [apoptotic process]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0043204 [perikaryon]
GO:0046872 [metal ion binding]
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 151 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.