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NUDT5

GENERAL INFORMATION

Gene name

 NUDT5

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 5

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several cell types, most abundant in liver.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA019827
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NUDT5 (HGNC Symbol)

Synonyms

 hYSAH1, YSA1H

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 5 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Chromosome

 10

Cytoband

 p14

Chromosome location (bp)

 12165325 - 12196144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165609 (version 83.38)

Entrez gene

 11164

UniProt

 Q9UKK9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKK9

Antibodypedia

 NUDT5 antibodies

PROTEIN BROWSER
NUDT5-001
NUDT5-002
NUDT5-003
NUDT5-004
NUDT5-006
NUDT5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT5-001
ENSP00000419628
ENST00000491614
Q9UKK9 [Direct mapping]
ADP-sugar pyrophosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0009117 [nucleotide metabolic process]
GO:0009191 [ribonucleoside diphosphate catabolic process]
GO:0016787 [hydrolase activity]
GO:0017110 [nucleoside-diphosphatase activity]
GO:0019144 [ADP-sugar diphosphatase activity]
GO:0019303 [D-ribose catabolic process]
GO:0030515 [snoRNA binding]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 219 aa
24.3 kDa 		No 0
NUDT5-002
ENSP00000368209
ENST00000378927
A6NCQ0 [Direct mapping]
ADP-sugar pyrophosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 180 aa
20 kDa 		No 0
NUDT5-003
ENSP00000368219
ENST00000378937
A6NFX8 [Direct mapping]
ADP-sugar pyrophosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 232 aa
25.9 kDa 		No 0
NUDT5-004
ENSP00000407856
ENST00000444732
C9JYY9 [Direct mapping]
ADP-sugar pyrophosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 98 aa
11.3 kDa 		No 0
NUDT5-006
ENSP00000368222
ENST00000378940
A6NJU6 [Direct mapping]
ADP-sugar pyrophosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 186 aa
20.6 kDa 		No 0
NUDT5-201
ENSP00000445116
ENST00000537776
Q9UKK9 [Direct mapping]
ADP-sugar pyrophosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0009117 [nucleotide metabolic process]
GO:0009191 [ribonucleoside diphosphate catabolic process]
GO:0016787 [hydrolase activity]
GO:0019144 [ADP-sugar diphosphatase activity]
GO:0019303 [D-ribose catabolic process]
GO:0030515 [snoRNA binding]
GO:0034656 [nucleobase-containing small molecule catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 219 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.