Expression of UCMA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Upper zone of growth plate and cartilage matrix associated

Protein class

Predicted secreted proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046718

GENE INFORMATION
Gene name	UCMA (HGNC Symbol)
Synonyms	C10orf49
Description	Upper zone of growth plate and cartilage matrix associated (HGNC Symbol)
Entrez gene summary	This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Chromosome	10
Cytoband	p13
Chromosome location (bp)	13221767 - 13234334
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000165623 (version 83.38)
Entrez gene	221044
UniProt	Q8WVF2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WVF2
Antibodypedia	UCMA antibodies

PROTEIN BROWSER

UCMA-001	UCMA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UCMA-001 ENSP00000367952 ENST00000378681	Q8WVF2 [Direct mapping] Unique cartilage matrix-associated protein Unique cartilage matrix-associated protein C-terminal fragment A0A067XJX6 [Target identity:100%; Query identity:100%] Gla-rich protein isoform 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0016235 [aggresome] GO:0045668 [negative regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] Show all	138 aa 16.6 kDa	Yes	0
UCMA-002 ENSP00000473368 ENST00000463405	R4GMV7 [Direct mapping] Unique cartilage matrix-associated protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0006886 [intracellular protein transport] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	116 aa 14.3 kDa	Yes	0