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ATP5C1

GENERAL INFORMATION

Gene name

 ATP5C1

Gene description

 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most glandular epithelia, liver, kidney, brain and muscle tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA060949
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP5C1 (HGNC Symbol)

Synonyms

 ATP5C, ATP5CL1

Description

 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p14

Chromosome location (bp)

 7788129 - 7807815

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165629 (version 83.38)

Entrez gene

 509

UniProt

 P36542 (UniProt - Evidence at protein level)

neXtProt

 NX_P36542

Antibodypedia

 ATP5C1 antibodies

PROTEIN BROWSER
ATP5C1-001
ATP5C1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5C1-001
ENSP00000349142
ENST00000356708
P36542 [Direct mapping]
ATP synthase subunit gamma, mitochondrial
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0006119 [oxidative phosphorylation]
GO:0006754 [ATP biosynthetic process]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
Show all
 298 aa
33 kDa 		No 0
ATP5C1-002
ENSP00000338568
ENST00000335698
P36542 [Direct mapping]
ATP synthase subunit gamma, mitochondrial
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0006119 [oxidative phosphorylation]
GO:0006754 [ATP biosynthetic process]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
Show all
 297 aa
32.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.