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PRPF18

GENERAL INFORMATION

Gene name

 PRPF18

Gene description

 Pre-mRNA processing factor 18

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA037599 , HPA047950
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRPF18 (HGNC Symbol)

Synonyms

 hPrp18

Description

 Pre-mRNA processing factor 18 (HGNC Symbol)

Entrez gene summary

 Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p13

Chromosome location (bp)

 13586927 - 13630868

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165630 (version 83.38)

Entrez gene

 8559

UniProt

 Q99633 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99633

Antibodypedia

 PRPF18 antibodies

PROTEIN BROWSER
PRPF18-001
PRPF18-002
PRPF18-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRPF18-001
ENSP00000367835
ENST00000378572
Q99633 [Direct mapping]
Pre-mRNA-splicing factor 18
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000350 [generation of catalytic spliceosome for second transesterification step]
GO:0000386 [second spliceosomal transesterification activity]
GO:0005634 [nucleus]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071021 [U2-type post-spliceosomal complex]
GO:0071048 [nuclear retention of unspliced pre-mRNA at the site of transcription]
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 342 aa
39.9 kDa 		No 0
PRPF18-002
ENSP00000367824
ENST00000320054
Q5T9P8 [Direct mapping]
Pre-mRNA-splicing factor 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008380 [RNA splicing]
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 167 aa
19.4 kDa 		No 0
PRPF18-003
ENSP00000392142
ENST00000417658
Q5T9P7 [Direct mapping]
Pre-mRNA-splicing factor 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005681 [spliceosomal complex]
GO:0008380 [RNA splicing]
Show all
 249 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.