Cell atlas - TAF3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TAF3

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoplasm

Human cell
	Nuclear membrane
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	TAF3
Gene description	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear membrane & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Nuclear membrane (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA066184
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear membrane & nucleoplasm.

Main location

Nucleoplasm (supported), Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066184	MCF7	Nucleoplasm
	HPA066184	MCF7	Nuclear membrane
	HPA066184	SiHa	Nucleoplasm
	HPA066184	SiHa	Nuclear membrane
	HPA066184	U-2 OS	Nucleoplasm
	HPA066184	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	TAF3 (HGNC Symbol)
Synonyms	TAF140, TAFII140
Description	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa (HGNC Symbol)
Entrez gene summary	The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Chromosome	10
Cytoband	p14
Chromosome location (bp)	7818504 - 8016627
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165632 (version 83.38)
Entrez gene	83860
UniProt	Q5VWG9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VWG9
Antibodypedia	TAF3 antibodies

PROTEIN BROWSER

TAF3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAF3-001 ENSP00000340271 ENST00000344293	Q5VWG9 [Direct mapping] Transcription initiation factor TFIID subunit 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0051457 [maintenance of protein location in nucleus] Show all	929 aa 103.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.