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VDAC2

GENERAL INFORMATION

Gene name

 VDAC2

Gene description

 Voltage-dependent anion channel 2

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA043475
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VDAC2

Synonyms

Description

 Voltage-dependent anion channel 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 75210154 - 75231448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165637 (version 83.38)

Entrez gene

 7417

UniProt

 P45880 (UniProt - Evidence at protein level)

neXtProt

 NX_P45880

Antibodypedia

 VDAC2 antibodies

PROTEIN BROWSER
VDAC2-001
VDAC2-002
VDAC2-003
VDAC2-005
VDAC2-010
VDAC2-013
VDAC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VDAC2-001
ENSP00000361686
ENST00000332211
P45880 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
A0A024QZT0 [Target identity:100%; Query identity:100%]
Voltage-dependent anion channel 2, isoform CRA_c
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006820 [anion transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0015288 [porin activity]
GO:0042645 [mitochondrial nucleoid]
GO:0044070 [regulation of anion transport]
GO:0045121 [membrane raft]
GO:0046930 [pore complex]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 294 aa
31.6 kDa 		No 0
VDAC2-002
ENSP00000361635
ENST00000313132
P45880 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0006820 [anion transport]
GO:0008021 [synaptic vesicle]
GO:0008308 [voltage-gated anion channel activity]
GO:0015288 [porin activity]
GO:0032272 [negative regulation of protein polymerization]
GO:0042645 [mitochondrial nucleoid]
GO:0043209 [myelin sheath]
GO:0044070 [regulation of anion transport]
GO:0045121 [membrane raft]
GO:0046930 [pore complex]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1903959 [regulation of anion transmembrane transport]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 309 aa
33.4 kDa 		No 0
VDAC2-003
ENSP00000298468
ENST00000298468
A0A0A0MR02 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0006820 [anion transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0016021 [integral component of membrane]
GO:0044070 [regulation of anion transport]
GO:0055085 [transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 282 aa
30.3 kDa 		No 0
VDAC2-005
ENSP00000344876
ENST00000344036
Q5JSD2 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006820 [anion transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 195 aa
21.3 kDa 		No 0
VDAC2-010
ENSP00000401492
ENST00000447677
Q5JSD1 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006820 [anion transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 204 aa
22.2 kDa 		No 0
VDAC2-013
ENSP00000389551
ENST00000413289
A2A3S1 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0006820 [anion transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 109 aa
12 kDa 		No 0
VDAC2-201
ENSP00000443092
ENST00000543351
P45880 [Direct mapping]
Voltage-dependent anion-selective channel protein 2
A0A024QZT0 [Target identity:100%; Query identity:100%]
Voltage-dependent anion channel 2, isoform CRA_c
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006820 [anion transport]
GO:0008308 [voltage-gated anion channel activity]
GO:0015288 [porin activity]
GO:0042645 [mitochondrial nucleoid]
GO:0044070 [regulation of anion transport]
GO:0045121 [membrane raft]
GO:0046930 [pore complex]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1903959 [regulation of anion transmembrane transport]
Show all
 294 aa
31.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.