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ENOX2

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GENERAL INFORMATION

Gene name

 ENOX2

Gene description

 Ecto-NOX disulfide-thiol exchanger 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the actin filaments. In addition localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Actin filaments (approved)

Additional location

 In addition localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA000514
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the actin filaments. In addition localized to the nucleus.

Main location

 Actin filaments (approved)

Additional location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA000514 A-431 Nucleus
Actin filaments
HPA000514 U-2 OS Nucleus
Actin filaments
HPA000514 U-251 MG Nucleus
Actin filaments

GENE INFORMATION

Gene name

 ENOX2 (HGNC Symbol)

Synonyms

 APK1, COVA1, tNOX

Description

 Ecto-NOX disulfide-thiol exchanger 2 (HGNC Symbol)

Entrez gene summary

 This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 q26.1

Chromosome location (bp)

 130623369 - 130903317

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165675 (version 83.38)

Entrez gene

 10495

UniProt

 Q16206 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16206

Antibodypedia

 ENOX2 antibodies

PROTEIN BROWSER
ENOX2-002
ENOX2-003
ENOX2-004
ENOX2-201
ENOX2-202
ENOX2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENOX2-002
ENSP00000400304
ENST00000432489
B1AKF7 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 376 aa
42.9 kDa 		No 0
ENOX2-003
ENSP00000359973
ENST00000370935
Q16206 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 2 Hydroquinone [NADH] oxidase Protein disulfide-thiol oxidoreductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007624 [ultradian rhythm]
GO:0009897 [external side of plasma membrane]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016049 [cell growth]
GO:0040008 [regulation of growth]
GO:0055114 [oxidation-reduction process]
Show all
 581 aa
66.6 kDa 		No 0
ENOX2-004
ENSP00000359965
ENST00000370927
Q16206 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 2 Hydroquinone [NADH] oxidase Protein disulfide-thiol oxidoreductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007624 [ultradian rhythm]
GO:0009897 [external side of plasma membrane]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016049 [cell growth]
GO:0040008 [regulation of growth]
GO:0055114 [oxidation-reduction process]
Show all
 610 aa
70.1 kDa 		No 0
ENOX2-201
ENSP00000337146
ENST00000338144
Q16206 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 2 Hydroquinone [NADH] oxidase Protein disulfide-thiol oxidoreductase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007624 [ultradian rhythm]
GO:0009897 [external side of plasma membrane]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016049 [cell growth]
GO:0040008 [regulation of growth]
GO:0055114 [oxidation-reduction process]
Show all
 610 aa
70.1 kDa 		No 0
ENOX2-202
ENSP00000377890
ENST00000394363
Q16206 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 2 Hydroquinone [NADH] oxidase Protein disulfide-thiol oxidoreductase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007624 [ultradian rhythm]
GO:0009897 [external side of plasma membrane]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016049 [cell growth]
GO:0040008 [regulation of growth]
GO:0055114 [oxidation-reduction process]
Show all
 581 aa
66.6 kDa 		No 0
ENOX2-203
ENSP00000478608
ENST00000610637
A0A0C4DGT9 [Direct mapping]
Ecto-NOX disulfide-thiol exchanger 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 263 aa
30.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.