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Few cases of endometrial, urothelial, liver cancer and gliomas showed moderate cytoplasmic positivity. Remaining normal cells were weakly stained or negative.
A majority of the cancer cells displayed weak to moderate cytoplasmic and/or nuclear positivity. Lymphomas and most cases of melanomas, ovarian, lung and testis cancers were negative.
GENE INFORMATION
Gene name
NDRG2 (HGNC Symbol)
Synonyms
KIAA1248, SYLD
Description
NDRG family member 2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]