Tissue expression of METTL3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	METTL3
Gene description	Methyltransferase like 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	METTL3 (HGNC Symbol)
Synonyms	M6A, MT-A70, Spo8
Description	Methyltransferase like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	21498133 - 21511375
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165819 (version 83.38)
Entrez gene	56339
UniProt	Q86U44 (UniProt - Evidence at protein level)
neXtProt	NX_Q86U44
Antibodypedia	METTL3 antibodies

PROTEIN BROWSER

METTL3-001	METTL3-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
METTL3-001 ENSP00000298717 ENST00000298717	Q86U44 [Direct mapping] N6-adenosine-methyltransferase 70 kDa subunit Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0001510 [RNA methylation] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006382 [adenosine to inosine editing] GO:0006397 [mRNA processing] GO:0007623 [circadian rhythm] GO:0008168 [methyltransferase activity] GO:0008173 [RNA methyltransferase activity] GO:0010467 [gene expression] GO:0016422 [mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity] GO:0016607 [nuclear speck] GO:0019827 [stem cell population maintenance] GO:0031053 [primary miRNA processing] GO:0036396 [MIS complex] GO:0061157 [mRNA destabilization] GO:0080009 [mRNA methylation] GO:1990744 [primary miRNA methylation] Show all	580 aa 64.5 kDa	No	0
METTL3-016 ENSP00000366766 ENST00000377543	A0A0G2JH39 [Direct mapping] N6-adenosine-methyltransferase 70 kDa subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1 kDa	No	0