Tissue expression of HACD1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HACD1
Gene description	3-hydroxyacyl-CoA dehydratase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	HACD1 (HGNC Symbol)
Synonyms	CAP, PTPLA
Description	3-hydroxyacyl-CoA dehydratase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	p12.33
Chromosome location (bp)	17589032 - 17617377
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165996 (version 83.38)
Entrez gene	9200
UniProt	B0YJ81 (UniProt - Evidence at protein level)
neXtProt	NX_B0YJ81
Antibodypedia	HACD1 antibodies

PROTEIN BROWSER

HACD1-001	HACD1-002	HACD1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HACD1-001 ENSP00000355308 ENST00000361271	B0YJ81 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006633 [fatty acid biosynthetic process] GO:0007275 [multicellular organismal development] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0014902 [myotube differentiation] GO:0016021 [integral component of membrane] GO:0016829 [lyase activity] GO:0018812 [3-hydroxyacyl-CoA dehydratase activity] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0030148 [sphingolipid biosynthetic process] GO:0030497 [fatty acid elongation] GO:0034622 [cellular macromolecular complex assembly] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042761 [very long-chain fatty acid biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046848 [hydroxyapatite binding] GO:0071529 [cementum mineralization] GO:2000045 [regulation of G1/S transition of mitotic cell cycle] Show all	288 aa 32.4 kDa	No	5
HACD1-002 ENSP00000322923 ENST00000326961	A6NP58 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 17 kDa	No	0
HACD1-003 ENSP00000462336 ENST00000466335	J3KS69 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	174 aa 19.6 kDa	No	3