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AMOTL1

CANCER ATLAS

Gene description

 Angiomotin like 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001196

GENE INFORMATION

Gene name

 AMOTL1 (HGNC Symbol)

Synonyms

 JEAP

Description

 Angiomotin like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 11

Cytoband

 q21

Chromosome location (bp)

 94706431 - 94876753

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166025 (version 83.38)

Entrez gene

 154810

UniProt

 Q8IY63 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IY63

Antibodypedia

 AMOTL1 antibodies

PROTEIN BROWSER
AMOTL1-001
AMOTL1-002
AMOTL1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMOTL1-001
ENSP00000387739
ENST00000433060
Q8IY63 [Direct mapping]
Angiomotin-like protein 1
A0A024R3A6 [Target identity:100%; Query identity:100%]
Angiomotin like 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003365 [establishment of cell polarity involved in ameboidal cell migration]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005923 [bicellular tight junction]
GO:0008180 [COP9 signalosome]
GO:0016055 [Wnt signaling pathway]
GO:0016324 [apical plasma membrane]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0035329 [hippo signaling]
GO:0042802 [identical protein binding]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
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 956 aa
106.6 kDa 		No 0
AMOTL1-002
ENSP00000320968
ENST00000317829
Q8IY63 [Direct mapping]
Angiomotin-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005923 [bicellular tight junction]
GO:0008180 [COP9 signalosome]
GO:0016055 [Wnt signaling pathway]
GO:0030054 [cell junction]
GO:0035329 [hippo signaling]
GO:0042802 [identical protein binding]
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 906 aa
101.2 kDa 		No 0
AMOTL1-007
ENSP00000299004
ENST00000299004
F8WDH4 [Direct mapping]
Angiomotin-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 145 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.