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CEP57

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GENERAL INFORMATION

Gene name

 CEP57

Gene description

 Centrosomal protein 57kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubules. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA018315
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubules. In addition localized to the cytosol.

Main location

 Microtubules (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA018315 A-431 Microtubules
HPA018315 U-2 OS Microtubules
HPA018315 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 CEP57 (HGNC Symbol)

Synonyms

 KIAA0092, Translokin, TSP57

Description

 Centrosomal protein 57kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q21

Chromosome location (bp)

 95789965 - 95832693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166037 (version 83.38)

Entrez gene

 9702

UniProt

 Q86XR8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86XR8

Antibodypedia

 CEP57 antibodies

PROTEIN BROWSER
CEP57-001
CEP57-002
CEP57-004
CEP57-009
CEP57-011
CEP57-012
CEP57-013
CEP57-201
CEP57-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEP57-001
ENSP00000317902
ENST00000325542
Q86XR8 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000070 [mitotic sister chromatid segregation]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007286 [spermatid development]
GO:0008017 [microtubule binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0015630 [microtubule cytoskeleton]
GO:0017134 [fibroblast growth factor binding]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043015 [gamma-tubulin binding]
GO:0051260 [protein homooligomerization]
Show all
 500 aa
57.1 kDa 		No 0
CEP57-002
ENSP00000441392
ENST00000537677
F5GYW0 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0043015 [gamma-tubulin binding]
Show all
 473 aa
54.5 kDa 		No 0
CEP57-004
ENSP00000445706
ENST00000538658
Q86XR8 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000070 [mitotic sister chromatid segregation]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007286 [spermatid development]
GO:0008017 [microtubule binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0015630 [microtubule cytoskeleton]
GO:0017134 [fibroblast growth factor binding]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043015 [gamma-tubulin binding]
Show all
 270 aa
31.1 kDa 		No 0
CEP57-009
ENSP00000438065
ENST00000544522
F5H0C6 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0015630 [microtubule cytoskeleton]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0043015 [gamma-tubulin binding]
Show all
 198 aa
23.2 kDa 		No 0
CEP57-011
ENSP00000445821
ENST00000541365
F5H1B0 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0015630 [microtubule cytoskeleton]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0043015 [gamma-tubulin binding]
Show all
 205 aa
24.2 kDa 		No 0
CEP57-012
ENSP00000444749
ENST00000537093
H0YGT4 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0043015 [gamma-tubulin binding]
Show all
 134 aa
15 kDa 		No 0
CEP57-013
ENSP00000440256
ENST00000535224
H0YFT8 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008017 [microtubule binding]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0043015 [gamma-tubulin binding]
Show all
 254 aa
28.7 kDa 		No 0
CEP57-201
ENSP00000317487
ENST00000325486
Q86XR8 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000070 [mitotic sister chromatid segregation]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007286 [spermatid development]
GO:0008017 [microtubule binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0015630 [microtubule cytoskeleton]
GO:0017134 [fibroblast growth factor binding]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043015 [gamma-tubulin binding]
Show all
 474 aa
54.2 kDa 		No 0
CEP57-202
ENSP00000443436
ENST00000541150
Q86XR8 [Direct mapping]
Centrosomal protein of 57 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000070 [mitotic sister chromatid segregation]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007286 [spermatid development]
GO:0008017 [microtubule binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0015630 [microtubule cytoskeleton]
GO:0017134 [fibroblast growth factor binding]
GO:0034453 [microtubule anchoring]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043015 [gamma-tubulin binding]
Show all
 491 aa
56.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.