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Malignant cells displayed moderate cytoplasmic positivity with additional membranous staining in many cases. Occasional cases of malignant melanoma, malignant glioma, ovarian, colorectal, gastric, pancreatic and liver cancers were strongly stained. Several cases of malignant lymphoma and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
ADAMTS15
Synonyms
Description
ADAM metallopeptidase with thrombospondin type 1 motif, 15 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008]
