Expression of SPINT1 in cancer - Summary

CANCER ATLAS

Gene description

Serine peptidase inhibitor, Kunitz type 1

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Urothelial cancer

STAINING SUMMARY

HPA006903

GENE INFORMATION
Gene name	SPINT1 (HGNC Symbol)
Synonyms	HAI, MANSC2
Description	Serine peptidase inhibitor, Kunitz type 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40844018 - 40858207
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166145 (version 83.38)
Entrez gene	6692
UniProt	O43278 (UniProt - Evidence at protein level)
neXtProt	NX_O43278
Antibodypedia	SPINT1 antibodies

PROTEIN BROWSER

SPINT1-001	SPINT1-003	SPINT1-005	SPINT1-006	SPINT1-007	SPINT1-008	SPINT1-009	SPINT1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINT1-001 ENSP00000342098 ENST00000344051	O43278 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0001892 [embryonic placenta development] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0045687 [positive regulation of glial cell differentiation] GO:0060670 [branching involved in labyrinthine layer morphogenesis] GO:0060674 [placenta blood vessel development] GO:0070062 [extracellular exosome] GO:0071773 [cellular response to BMP stimulus] GO:2000178 [negative regulation of neural precursor cell proliferation] Show all	529 aa 58.4 kDa	Yes	1
SPINT1-003 ENSP00000457076 ENST00000562057	O43278 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	513 aa 56.9 kDa	Yes	1
SPINT1-005 ENSP00000458074 ENST00000568580	H3BVD9 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] Show all	472 aa 52.4 kDa	No	1
SPINT1-006 ENSP00000457284 ENST00000563656	H3BTQ8 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	302 aa 33.2 kDa	Yes	0
SPINT1-007 ENSP00000456015 ENST00000566928	H3BR01 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] Show all	240 aa 27.2 kDa	No	1
SPINT1-008 ENSP00000454315 ENST00000564375	H3BMB6 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] Show all	294 aa 33.1 kDa	No	1
SPINT1-009 ENSP00000455038 ENST00000569589	H3BNW5 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] Show all	204 aa 22.8 kDa	No	1
SPINT1-013 ENSP00000456769 ENST00000568823	H3BSM2 [Direct mapping] Kunitz-type protease inhibitor 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	313 aa 33.9 kDa	No	0