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BTRC

CANCER ATLAS

Gene description

 Beta-transducin repeat containing E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB032986

GENE INFORMATION

Gene name

 BTRC (HGNC Symbol)

Synonyms

 beta-TrCP1, betaTrCP, bTrCP, bTrCP1, FBXW1A, Fwd1

Description

 Beta-transducin repeat containing E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 101354033 - 101557321

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166167 (version 83.38)

Entrez gene

 8945

UniProt

 Q9Y297 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y297

Antibodypedia

 BTRC antibodies

PROTEIN BROWSER
BTRC-001
BTRC-002
BTRC-005
BTRC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BTRC-001
ENSP00000359206
ENST00000370187
Q9Y297 [Direct mapping]
F-box/WD repeat-containing protein 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007165 [signal transduction]
GO:0007623 [circadian rhythm]
GO:0008013 [beta-catenin binding]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0030163 [protein catabolic process]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045087 [innate immune response]
GO:0045309 [protein phosphorylated amino acid binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071407 [cellular response to organic cyclic compound]
Show all
 605 aa
68.9 kDa 		No 0
BTRC-002
ENSP00000385339
ENST00000408038
Q9Y297 [Direct mapping]
F-box/WD repeat-containing protein 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007165 [signal transduction]
GO:0007623 [circadian rhythm]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
Show all
 569 aa
65 kDa 		No 0
BTRC-005
ENSP00000359202
ENST00000370183
Q5T1W7 [Direct mapping]
F-box/WD repeat-containing protein 1A
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0046983 [protein dimerization activity]
Show all
 191 aa
21.5 kDa 		No 0
BTRC-201
ENSP00000377088
ENST00000393441
B7Z3H4 [Direct mapping]
Beta-transducin repeat containing, isoform CRA_b; F-box/WD repeat-containing protein 1A; cDNA FLJ54002, highly similar to F-box/WD repeat protein 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0046983 [protein dimerization activity]
Show all
 579 aa
65.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.