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API5

CANCER ATLAS

Gene description

 Apoptosis inhibitor 5

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA026598

GENE INFORMATION

Gene name

 API5 (HGNC Symbol)

Synonyms

 AAC-11, AAC11, API5L1

Description

 Apoptosis inhibitor 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 p12

Chromosome location (bp)

 43311963 - 43344529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166181 (version 83.38)

Entrez gene

 8539

UniProt

 Q9BZZ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZZ5

Antibodypedia

 API5 antibodies

PROTEIN BROWSER
API5-001
API5-002
API5-003
API5-004
API5-005
API5-010
API5-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
API5-001
ENSP00000368129
ENST00000378852
Q9BZZ5 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
Show all
 504 aa
56.8 kDa 		No 0
API5-002
ENSP00000431391
ENST00000531273
Q9BZZ5 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:2000270 [negative regulation of fibroblast apoptotic process]
Show all
 524 aa
59 kDa 		No 0
API5-003
ENSP00000402540
ENST00000420461
Q9BZZ5 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
Show all
 450 aa
50.7 kDa 		No 0
API5-004
ENSP00000399341
ENST00000455725
Q9BZZ5 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0017134 [fibroblast growth factor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
Show all
 513 aa
57.9 kDa 		No 0
API5-005
ENSP00000434462
ENST00000534600
G3V1C3 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
Show all
 510 aa
57.6 kDa 		No 0
API5-010
ENSP00000436189
ENST00000534695
E9PQK6 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 123 aa
13.8 kDa 		No 0
API5-011
ENSP00000436436
ENST00000526394
H0YER7 [Direct mapping]
Apoptosis inhibitor 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 294 aa
33.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.