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COPS2

CANCER ATLAS

Gene description

 COP9 signalosome subunit 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA016867
HPA018271

GENE INFORMATION

Gene name

 COPS2 (HGNC Symbol)

Synonyms

 ALIEN, CSN2, TRIP15

Description

 COP9 signalosome subunit 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 49106068 - 49155661

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166200 (version 83.38)

Entrez gene

 9318

UniProt

 P61201 (UniProt - Evidence at protein level)

neXtProt

 NX_P61201

Antibodypedia

 COPS2 antibodies

PROTEIN BROWSER
COPS2-001
COPS2-002
COPS2-003
COPS2-005
COPS2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COPS2-001
ENSP00000373553
ENST00000388901
P61201 [Direct mapping]
COP9 signalosome complex subunit 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008180 [COP9 signalosome]
GO:0010388 [cullin deneddylation]
GO:0070911 [global genome nucleotide-excision repair]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 443 aa
51.6 kDa 		No 0
COPS2-002
ENSP00000443664
ENST00000542928
B4DIH5 [Direct mapping]
COP9 signalosome complex subunit 2; cDNA FLJ52928, highly similar to COP9 signalosome complex subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 379 aa
44.2 kDa 		No 0
COPS2-003
ENSP00000299259
ENST00000299259
P61201 [Direct mapping]
COP9 signalosome complex subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003714 [transcription corepressor activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008180 [COP9 signalosome]
GO:0008283 [cell proliferation]
GO:0010388 [cullin deneddylation]
GO:0030182 [neuron differentiation]
GO:0035914 [skeletal muscle cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070911 [global genome nucleotide-excision repair]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 450 aa
52.4 kDa 		No 0
COPS2-005
ENSP00000453412
ENST00000561248
H0YM03 [Direct mapping]
COP9 signalosome complex subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 183 aa
21.6 kDa 		No 0
COPS2-006
ENSP00000452944
ENST00000558843
H0YKU5 [Direct mapping]
COP9 signalosome complex subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 263 aa
30.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.