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Most cancer tissues showed moderate cytoplasmic immunoreactivity. Papillary adenocarcinomas of thyroid along with several malignant melanomas, colorectal and few ovarian cancers were strongly stained. Several squamous cell carcinomas of cervix and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
COX11 (HGNC Symbol)
Synonyms
COX11P
Description
COX11 cytochrome c oxidase copper chaperone (HGNC Symbol)
Entrez gene summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]
B4DI26 [Direct mapping] Cytochrome c oxidase assembly protein COX11, mitochondrial; cDNA FLJ56729, highly similar to Cytochrome c oxidase assembly protein COX11, mitochondrial
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
