Expression of DCHS1 in cancer - Summary

CANCER ATLAS

Gene description

Dachsous cadherin-related 1

Protein class

Disease related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017970	HPA050246

GENE INFORMATION
Gene name	DCHS1 (HGNC Symbol)
Synonyms	CDH25, CDHR6, FIB1, FLJ11790, KIAA1773, PCDH16
Description	Dachsous cadherin-related 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	6621323 - 6655854
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166341 (version 83.38)
Entrez gene	8642
UniProt	Q96JQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JQ0
Antibodypedia	DCHS1 antibodies

PROTEIN BROWSER

DCHS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCHS1-001 ENSP00000299441 ENST00000299441	Q96JQ0 [Direct mapping] Protocadherin-16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0003007 [heart morphogenesis] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0021915 [neural tube development] GO:0022008 [neurogenesis] GO:0035329 [hippo signaling] GO:0036342 [post-anal tail morphogenesis] GO:0043931 [ossification involved in bone maturation] GO:0045177 [apical part of cell] GO:0048565 [digestive tract development] GO:0090102 [cochlea development] Show all	3298 aa 346.2 kDa	Yes	1