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MOGAT2

GENERAL INFORMATION

Gene name

 MOGAT2

Gene description

 Monoacylglycerol O-acyltransferase 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum, rectum, colon, liver)
GTEx:Group enriched (liver, small intestine, colon)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA028834
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum, rectum, colon, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 MOGAT2 (HGNC Symbol)

Synonyms

 DGAT2L5, FLJ22644, MGAT2

Description

 Monoacylglycerol O-acyltransferase 2 (HGNC Symbol)

Entrez gene summary

 Dietary fat absorption from the small intestine is facilitated by acyl-CoA:monoacylglycerol transferase (MOGAT; EC 2.3.1.22) and acyl-CoA:diacylglycerol acyltransferase (DGAT; see MIM 604900) activities. MOGAT catalyzes the joining of monoacylglycerol and fatty acyl-CoAs to form diacylglycerol (Yen and Farese, 2003 [PubMed 12621063]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 q13.5

Chromosome location (bp)

 75717819 - 75732958

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166391 (version 83.38)

Entrez gene

 80168

UniProt

 Q3SYC2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q3SYC2

Antibodypedia

 MOGAT2 antibodies

PROTEIN BROWSER
MOGAT2-001
MOGAT2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOGAT2-001
ENSP00000198801
ENST00000198801
Q3SYC2 [Direct mapping]
2-acylglycerol O-acyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003846 [2-acylglycerol O-acyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006071 [glycerol metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006651 [diacylglycerol biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016407 [acetyltransferase activity]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0050892 [intestinal absorption]
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 334 aa
38.2 kDa 		No 1
MOGAT2-004
ENSP00000436283
ENST00000526712
Q3SYC2 [Direct mapping]
2-acylglycerol O-acyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003846 [2-acylglycerol O-acyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006071 [glycerol metabolic process]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0019432 [triglyceride biosynthetic process]
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 252 aa
28.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.