Expression of CYB5R2 in cancer - Summary

CANCER ATLAS

Gene description

Cytochrome b5 reductase 2

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038962

GENE INFORMATION
Gene name	CYB5R2
Synonyms
Description	Cytochrome b5 reductase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	7665100 - 7677222
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166394 (version 83.38)
Entrez gene	51700
UniProt	Q6BCY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6BCY4
Antibodypedia	CYB5R2 antibodies

PROTEIN BROWSER

CYB5R2-001	CYB5R2-003	CYB5R2-004	CYB5R2-006	CYB5R2-007	CYB5R2-009	CYB5R2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYB5R2-001 ENSP00000437041 ENST00000533558	Q6BCY4 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0016020 [membrane] GO:0016126 [sterol biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	276 aa 31.5 kDa	No	0
CYB5R2-003 ENSP00000299498 ENST00000299498	Q6BCY4 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0016126 [sterol biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	276 aa 31.5 kDa	No	0
CYB5R2-004 ENSP00000435916 ENST00000524790	Q6BCY4 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0016126 [sterol biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	237 aa 27 kDa	No	0
CYB5R2-006 ENSP00000432482 ENST00000524608	E9PQW2 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	189 aa 21.5 kDa	No	1
CYB5R2-007 ENSP00000434969 ENST00000531096	E9PMI2 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	171 aa 19.4 kDa	No	0
CYB5R2-009 ENSP00000433856 ENST00000527542	E9PIV9 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	146 aa 16.8 kDa	No	0
CYB5R2-010 ENSP00000392777 ENST00000436351	E9PRM4 [Direct mapping] NADH-cytochrome b5 reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	116 aa 13.4 kDa	No	0