Tissue expression of SERPINB7 - Summary - The Human Protein Atlas

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SERPINB7

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SERPINB7
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 7
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin, tonsil)
GTEx:	Tissue enriched (skin)
FANTOM5:	Group enriched (tonsil, placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in subsets of keratinocytes in skin and tonsil.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA024200
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (tonsil, placenta)

GENE INFORMATION
Gene name	SERPINB7 (HGNC Symbol)
Synonyms	MEGSIN
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	18
Cytoband	q21.33
Chromosome location (bp)	63752935 - 63805376
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166396 (version 83.38)
Entrez gene	8710
UniProt	O75635 (UniProt - Evidence at protein level)
neXtProt	NX_O75635
Antibodypedia	SERPINB7 antibodies

PROTEIN BROWSER

SERPINB7-001	SERPINB7-002	SERPINB7-004	SERPINB7-005	SERPINB7-201	SERPINB7-202	SERPINB7-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB7-001 ENSP00000381101 ENST00000398019	O75635 [Direct mapping] Serpin B7 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] GO:0032914 [positive regulation of transforming growth factor beta1 production] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0072126 [positive regulation of glomerular mesangial cell proliferation] GO:0090362 [positive regulation of platelet-derived growth factor production] Show all	380 aa 42.9 kDa	No	0
SERPINB7-002 ENSP00000397301 ENST00000425392	C9JA68 [Direct mapping] Serpin B7 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	128 aa 14.1 kDa	No	0
SERPINB7-004 ENSP00000402362 ENST00000447428	C9JM00 [Direct mapping] Serpin B7 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	165 aa 18.3 kDa	No	0
SERPINB7-005 ENSP00000393947 ENST00000431370	C9JA68 [Direct mapping] Serpin B7 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	128 aa 14.1 kDa	No	0
SERPINB7-201 ENSP00000337212 ENST00000336429	O75635 [Direct mapping] Serpin B7 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] Show all	380 aa 42.9 kDa	No	0
SERPINB7-202 ENSP00000444572 ENST00000540675	O75635 [Direct mapping] Serpin B7 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] Show all	363 aa 41.2 kDa	No	0
SERPINB7-203 ENSP00000444861 ENST00000546027	O75635 [Direct mapping] Serpin B7 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] Show all	380 aa 42.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.