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RNA tissue category: Group enriched (tonsil, placenta)
GENE INFORMATION
Gene name
SERPINB7 (HGNC Symbol)
Synonyms
MEGSIN
Description
Serpin peptidase inhibitor, clade B (ovalbumin), member 7 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] GO:0032914 [positive regulation of transforming growth factor beta1 production] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0072126 [positive regulation of glomerular mesangial cell proliferation] GO:0090362 [positive regulation of platelet-derived growth factor production]
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014)