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Several cases of lymphomas, squamous cell carcinomas, urothelial and pancreatic cancers showed moderate immunoreactivity. Remaining cancer tissues were generally weakly stained or negative.
GENE INFORMATION
Gene name
SERPINB8 (HGNC Symbol)
Synonyms
CAP2, PI8
Description
Serpin peptidase inhibitor, clade B (ovalbumin), member 8 (HGNC Symbol)
Entrez gene summary
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]
Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P50452 [Direct mapping] Serpin B8 A0A024R2B1 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 8, isoform CRA_a
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
