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CENPN

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GENERAL INFORMATION

Gene name

 CENPN

Gene description

 Centromere protein N

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA052870
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA052870 HeLa Nucleoplasm
HPA052870 MCF7 Nucleoplasm
HPA052870 U-2 OS Nucleus

GENE INFORMATION

Gene name

 CENPN (HGNC Symbol)

Synonyms

 BM039, C16orf60, FLJ13607, FLJ22660

Description

 Centromere protein N (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Chromosome

 16

Cytoband

 q23.2

Chromosome location (bp)

 81006498 - 81033114

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166451 (version 83.38)

Entrez gene

 55839

UniProt

 Q96H22 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96H22

Antibodypedia

 CENPN antibodies

PROTEIN BROWSER
CENPN-001
CENPN-002
CENPN-003
CENPN-004
CENPN-005
CENPN-007
CENPN-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPN-001
ENSP00000305608
ENST00000305850
Q96H22 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034508 [centromere complex assembly]
Show all
 339 aa
39.6 kDa 		No 0
CENPN-002
ENSP00000377007
ENST00000393335
Q96H22 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034508 [centromere complex assembly]
Show all
 353 aa
41.2 kDa 		No 0
CENPN-003
ENSP00000299572
ENST00000299572
Q96H22 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034508 [centromere complex assembly]
Show all
 204 aa
24.1 kDa 		No 0
CENPN-004
ENSP00000395235
ENST00000439957
Q96H22 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034508 [centromere complex assembly]
Show all
 319 aa
37.1 kDa 		No 0
CENPN-005
ENSP00000393991
ENST00000428963
Q96H22 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000777 [condensed chromosome kinetochore]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0034508 [centromere complex assembly]
Show all
 305 aa
35.6 kDa 		No 0
CENPN-007
ENSP00000454327
ENST00000564669
H3BMC7 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0007059 [chromosome segregation]
GO:0034508 [centromere complex assembly]
Show all
 177 aa
20.9 kDa 		No 0
CENPN-009
ENSP00000456413
ENST00000562943
H3BRU7 [Direct mapping]
Centromere protein N
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007059 [chromosome segregation]
GO:0034508 [centromere complex assembly]
Show all
 105 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.