Expression of TMX3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Thioredoxin-related transmembrane protein 3

Protein class

Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014157

GENE INFORMATION
Gene name	TMX3 (HGNC Symbol)
Synonyms	FLJ20793, KIAA1830, PDIA13, TXNDC10
Description	Thioredoxin-related transmembrane protein 3 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q22.1
Chromosome location (bp)	68673688 - 68715298
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166479 (version 83.38)
Entrez gene	54495
UniProt	Q96JJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JJ7
Antibodypedia	TMX3 antibodies

PROTEIN BROWSER

TMX3-001	TMX3-003	TMX3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMX3-001 ENSP00000299608 ENST00000299608	Q96JJ7 [Direct mapping] Protein disulfide-isomerase TMX3 Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016972 [thiol oxidase activity] GO:0018171 [peptidyl-cysteine oxidation] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] Show all	454 aa 51.9 kDa	Yes	1
TMX3-003 ENSP00000457262 ENST00000562706	Q96JJ7 [Direct mapping] Protein disulfide-isomerase TMX3 Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016972 [thiol oxidase activity] GO:0018171 [peptidyl-cysteine oxidation] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] Show all	195 aa 22.3 kDa	Yes	0
TMX3-004 ENSP00000402605 ENST00000443099	B4DIE3 [Direct mapping] Protein disulfide-isomerase TMX3; cDNA FLJ60560, highly similar to Protein disulfide-isomerase TXNDC10 (EC 5.3.4.1) Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003756 [protein disulfide isomerase activity] GO:0005623 [cell] GO:0006457 [protein folding] GO:0008152 [metabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0045454 [cell redox homeostasis] Show all	197 aa 22.7 kDa	Yes	0