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PRKCB

CANCER ATLAS

Gene description

 Protein kinase C, beta

Protein class

 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048321
CAB003843

GENE INFORMATION

Gene name

 PRKCB (HGNC Symbol)

Synonyms

 PKCB, PRKCB1, PRKCB2

Description

 Protein kinase C, beta (HGNC Symbol)

Entrez gene summary

 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

Chromosome location (bp)

 23836001 - 24220611

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166501 (version 83.38)

Entrez gene

 5579

UniProt

 P05771 (UniProt - Evidence at protein level)

neXtProt

 NX_P05771

Antibodypedia

 PRKCB antibodies

PROTEIN BROWSER
PRKCB-001
PRKCB-002
PRKCB-003
PRKCB-004
PRKCB-007
PRKCB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKCB-001
ENSP00000318315
ENST00000321728
P05771 [Direct mapping]
Protein kinase C beta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0002250 [adaptive immune response]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0010829 [negative regulation of glucose transport]
GO:0030168 [platelet activation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035403 [histone kinase activity (H3-T6 specific)]
GO:0035408 [histone H3-T6 phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0042113 [B cell activation]
GO:0042393 [histone binding]
GO:0042953 [lipoprotein transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045766 [positive regulation of angiogenesis]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050681 [androgen receptor binding]
GO:0050853 [B cell receptor signaling pathway]
GO:0050861 [positive regulation of B cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070062 [extracellular exosome]
Show all
 671 aa
76.9 kDa 		No 0
PRKCB-002
ENSP00000305355
ENST00000303531
P05771 [Direct mapping]
Protein kinase C beta type
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0001666 [response to hypoxia]
GO:0002250 [adaptive immune response]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005080 [protein kinase C binding]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0010829 [negative regulation of glucose transport]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035403 [histone kinase activity (H3-T6 specific)]
GO:0035408 [histone H3-T6 phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0042113 [B cell activation]
GO:0042393 [histone binding]
GO:0042953 [lipoprotein transport]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045766 [positive regulation of angiogenesis]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050681 [androgen receptor binding]
GO:0050853 [B cell receptor signaling pathway]
GO:0050861 [positive regulation of B cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0071322 [cellular response to carbohydrate stimulus]
Show all
 673 aa
77 kDa 		No 0
PRKCB-003
ENSP00000454428
ENST00000498058
A0A0C4DGL5 [Direct mapping]
Protein kinase C beta type
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 57 aa
6.4 kDa 		No 0
PRKCB-004
ENSP00000459227
ENST00000498739
I3L1Z0 [Direct mapping]
Protein kinase C beta type
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 119 aa
13.8 kDa 		No 0
PRKCB-007
ENSP00000457980
ENST00000472066
H3BV73 [Direct mapping]
Protein kinase C beta type
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 130 aa
14.9 kDa 		No 0
PRKCB-010
ENSP00000458564
ENST00000466124
I3L148 [Direct mapping]
Protein kinase C beta type
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 122 aa
14 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.