Cell atlas - BEAN1 - The Human Protein Atlas

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BEAN1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BEAN1
Gene description	Brain expressed, associated with NEDD4, 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the centrosome.
RNA cell category	Cell line enhanced (AN3-CA, RPTEC TERT1, U-87 MG, BEWO)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoplasm (uncertain)
Additional location	In addition localized to the Centrosome (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA053851
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, RPTEC TERT1, U-87 MG, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the centrosome.

Main location

Nucleoplasm (uncertain)

Additional location

Centrosome (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053851	A549	Nucleoplasm
	HPA053851	A549	Centrosome
	HPA053851	SK-MEL-30	Nucleoplasm
	HPA053851	U-2 OS	Nucleoplasm
	HPA053851	U-2 OS	Centrosome

GENE INFORMATION
Gene name	BEAN1 (HGNC Symbol)
Synonyms	SCA31
Description	Brain expressed, associated with NEDD4, 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	16
Cytoband	q21
Chromosome location (bp)	66427297 - 66493529
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000166546 (version 83.38)
Entrez gene	146227
UniProt	Q3B7T3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3B7T3
Antibodypedia	BEAN1 antibodies

PROTEIN BROWSER

BEAN1-002	BEAN1-003	BEAN1-004	BEAN1-007	BEAN1-009	BEAN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEAN1-002 ENSP00000442793 ENST00000536005	Q3B7T3 [Direct mapping] Protein BEAN1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	259 aa 28.6 kDa	No	1
BEAN1-003 ENSP00000299694 ENST00000299694	Q3B7T3 [Direct mapping] Protein BEAN1 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0016021 [integral component of membrane] Show all	150 aa 15.5 kDa	No	0
BEAN1-004 ENSP00000455212 ENST00000561796	Q3B7T3 [Direct mapping] Protein BEAN1 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0016021 [integral component of membrane] Show all	208 aa 22.3 kDa	No	0
BEAN1-007 ENSP00000456430 ENST00000564819	H3BRW1 [Direct mapping] Protein BEAN1 Show all	Predicted intracellular proteins Show all		72 aa 7.6 kDa	No	0
BEAN1-009 ENSP00000462088 ENST00000562146	J3KRN6 [Direct mapping] Protein BEAN1 Show all	Predicted intracellular proteins Show all		82 aa 9 kDa	No	0
BEAN1-201 ENSP00000483700 ENST00000622872	Q3B7T3 [Direct mapping] Protein BEAN1 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0016021 [integral component of membrane] Show all	208 aa 22.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.