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TK2

GENERAL INFORMATION

Gene name

 TK2

Gene description

 Thymidine kinase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041162
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Colon
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TK2 (HGNC Symbol)

Synonyms

 SCA31

Description

 Thymidine kinase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 66508003 - 66552544

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166548 (version 83.38)

Entrez gene

 7084

UniProt

 O00142 (UniProt - Evidence at protein level)

neXtProt

 NX_O00142

Antibodypedia

 TK2 antibodies

PROTEIN BROWSER
«
TK2-001
TK2-002
TK2-003
TK2-004
TK2-005
TK2-006
TK2-008
TK2-009
TK2-014
TK2-016
TK2-017
TK2-019
TK2-020
TK2-201
TK2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TK2-001
ENSP00000414334
ENST00000451102
E5KNQ5 [Direct mapping]
Mitochondrial thymidine kinase 2; Thymidine kinase 2, mitochondrial; Thymidine kinase 2, mitochondrial, isoform CRA_e
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 307 aa
35.4 kDa 		No 0
TK2-002
ENSP00000433770
ENST00000527800
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 168 aa
20.3 kDa 		No 0
TK2-003
ENSP00000434594
ENST00000525974
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 168 aa
20.3 kDa 		No 0
TK2-004
ENSP00000435312
ENST00000527284
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 234 aa
27.6 kDa 		No 0
TK2-005
ENSP00000407469
ENST00000417693
A0A0A0MSY7 [Direct mapping]
Thymidine kinase 2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 289 aa
33.3 kDa 		No 0
TK2-006
ENSP00000464313
ENST00000569718
J3QRP0 [Direct mapping]
Thymidine kinase 2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
16.4 kDa 		No 0
TK2-008
ENSP00000438143
ENST00000545043
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 240 aa
28.4 kDa 		No 0
TK2-009
ENSP00000463560
ENST00000563369
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0019206 [nucleoside kinase activity]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 168 aa
20.3 kDa 		No 0
TK2-014
ENSP00000455187
ENST00000564917
H3BP77 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0009165 [nucleotide biosynthetic process]
GO:0019206 [nucleoside kinase activity]
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 282 aa
32.9 kDa 		No 0
TK2-016
ENSP00000462341
ENST00000563478
J3KS73 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 130 aa
15.8 kDa 		No 0
TK2-017
ENSP00000463326
ENST00000562484
J3QL12 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 89 aa
10.7 kDa 		No 0
TK2-019
ENSP00000462721
ENST00000561905
J3KSZ2 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 22 aa
2.4 kDa 		No 0
TK2-020
ENSP00000440898
ENST00000544898
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 265 aa
31 kDa 		No 0
TK2-201
ENSP00000299697
ENST00000299697
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004137 [deoxycytidine kinase activity]
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006264 [mitochondrial DNA replication]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0009262 [deoxyribonucleotide metabolic process]
GO:0016310 [phosphorylation]
GO:0032042 [mitochondrial DNA metabolic process]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0046092 [deoxycytidine metabolic process]
GO:0046104 [thymidine metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 265 aa
31 kDa 		No 0
TK2-202
ENSP00000483833
ENST00000620035
O00142 [Direct mapping]
Thymidine kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004797 [thymidine kinase activity]
GO:0005524 [ATP binding]
GO:0005759 [mitochondrial matrix]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016310 [phosphorylation]
GO:0043097 [pyrimidine nucleoside salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 247 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.