Cell atlas - SEC11C - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SEC11C
Gene description	SEC11 homolog C, signal peptidase complex subunit
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Golgi apparatus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047533
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear membrane (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA047533	Hep G2	Nuclear membrane	Intensity
HPA047533	Hep G2	Golgi apparatus	Intensity
HPA047533	MCF7	Nuclear membrane
HPA047533	U-2 OS	No staining

GENE INFORMATION
Gene name	SEC11C (HGNC Symbol)
Synonyms	SEC11L3, SPC21, SPCS4C
Description	SEC11 homolog C, signal peptidase complex subunit (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.32
Chromosome location (bp)	59139477 - 59158836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166562 (version 83.38)
Entrez gene	90701
UniProt	Q9BY50 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY50
Antibodypedia	SEC11C antibodies

PROTEIN BROWSER

SEC11C-001	SEC11C-005	SEC11C-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEC11C-001 ENSP00000468633 ENST00000587834	Q9BY50 [Direct mapping] Signal peptidase complex catalytic subunit SEC11C Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006465 [signal peptide processing] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0050796 [regulation of insulin secretion] Show all	192 aa 21.5 kDa	No	1
SEC11C-005 ENSP00000482872 ENST00000509791	B4DI03 [Direct mapping] Signal peptidase complex catalytic subunit SEC11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006465 [signal peptide processing] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	156 aa 17.4 kDa	No	1
SEC11C-006 ENSP00000465281 ENST00000588875	K7EJQ7 [Direct mapping] Signal peptidase complex catalytic subunit SEC11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006465 [signal peptide processing] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	161 aa 18.1 kDa	No	1