Cell atlas - MC4R - The Human Protein Atlas

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MC4R

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MC4R
Gene description	Melanocortin 4 receptor
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (BJ)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MC4R
Synonyms
Description	Melanocortin 4 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
Chromosome	18
Cytoband	q21.32
Chromosome location (bp)	60371110 - 60372775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166603 (version 83.38)
Entrez gene	4160
UniProt	P32245 (UniProt - Evidence at protein level)
neXtProt	NX_P32245
Antibodypedia	MC4R antibodies

PROTEIN BROWSER

MC4R-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MC4R-001 ENSP00000299766 ENST00000299766	P32245 [Direct mapping] Melanocortin receptor 4 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0002024 [diet induced thermogenesis] GO:0004930 [G-protein coupled receptor activity] GO:0004977 [melanocortin receptor activity] GO:0004980 [melanocyte-stimulating hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007631 [feeding behavior] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0019222 [regulation of metabolic process] GO:0030073 [insulin secretion] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032868 [response to insulin] GO:0042923 [neuropeptide binding] GO:0045780 [positive regulation of bone resorption] GO:0060259 [regulation of feeding behavior] GO:2000252 [negative regulation of feeding behavior] GO:2000821 [regulation of grooming behavior] Show all	332 aa 36.9 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.