Tissue expression of CHRFAM7A - Summary

GENERAL INFORMATION
Gene name	CHRFAM7A
Gene description	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	CHRFAM7A (HGNC Symbol)
Synonyms	CHRNA7-DR1, D-10
Description	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion (HGNC Symbol)
Entrez gene summary	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q13.2
Chromosome location (bp)	30357766 - 30393849
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000166664 (version 83.38)
Entrez gene	89832
UniProt	Q494W8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q494W8
Antibodypedia	CHRFAM7A antibodies

PROTEIN BROWSER

CHRFAM7A-001	CHRFAM7A-002	CHRFAM7A-004	CHRFAM7A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRFAM7A-001 ENSP00000385389 ENST00000401522	A0A0A6YYA8 [Direct mapping] CHRNA7-FAM7A fusion protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	321 aa 35.5 kDa	No	4
CHRFAM7A-002 ENSP00000299847 ENST00000299847	Q494W8 [Direct mapping] CHRNA7-FAM7A fusion protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0001988 [positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure] GO:0004889 [acetylcholine-activated cation-selective channel activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005515 [protein binding] GO:0005892 [acetylcholine-gated channel complex] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006897 [endocytosis] GO:0007165 [signal transduction] GO:0007271 [synaptic transmission, cholinergic] GO:0007613 [memory] GO:0008306 [associative learning] GO:0009897 [external side of plasma membrane] GO:0014061 [regulation of norepinephrine secretion] GO:0015464 [acetylcholine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030317 [sperm motility] GO:0030673 [axolemma] GO:0032094 [response to food] GO:0032225 [regulation of synaptic transmission, dopaminergic] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0035095 [behavioral response to nicotine] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042166 [acetylcholine binding] GO:0042391 [regulation of membrane potential] GO:0042698 [ovulation cycle] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045471 [response to ethanol] GO:0048149 [behavioral response to ethanol] GO:0050727 [regulation of inflammatory response] GO:0050728 [negative regulation of inflammatory response] GO:0050877 [neurological system process] GO:0060112 [generation of ovulation cycle rhythm] GO:0098655 [cation transmembrane transport] Show all	412 aa 46.2 kDa	No	4
CHRFAM7A-004 ENSP00000455401 ENST00000562729	H3BPP0 [Direct mapping] CHRNA7-FAM7A fusion protein Show all	Predicted intracellular proteins Show all	GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034766 [negative regulation of ion transmembrane transport] GO:1903049 [negative regulation of acetylcholine-gated cation channel activity] Show all	104 aa 12.1 kDa	No	0
CHRFAM7A-201 ENSP00000380927 ENST00000397827	A0A0A6YYA8 [Direct mapping] CHRNA7-FAM7A fusion protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	321 aa 35.5 kDa	No	4