Cell atlas - TMPRSS5 - The Human Protein Atlas

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TMPRSS5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TMPRSS5
Gene description	Transmembrane protease, serine 5
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (CAPAN-2, WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA010992
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA010992	SK-MEL-30	Nucleoplasm
	HPA010992	U-2 OS	Nucleoplasm
	HPA010992	U-251 MG	No staining

GENE INFORMATION
Gene name	TMPRSS5 (HGNC Symbol)
Synonyms	MGC141886, MGC148044
Description	Transmembrane protease, serine 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	113687550 - 113706373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166682 (version 83.38)
Entrez gene	80975
UniProt	Q9H3S3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3S3
Antibodypedia	TMPRSS5 antibodies

PROTEIN BROWSER

TMPRSS5-001	TMPRSS5-002	TMPRSS5-003	TMPRSS5-004	TMPRSS5-005	TMPRSS5-006	TMPRSS5-007	TMPRSS5-010	TMPRSS5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMPRSS5-001 ENSP00000299882 ENST00000299882	Q9H3S3 [Direct mapping] Transmembrane protease serine 5 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0008233 [peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043025 [neuronal cell body] Show all	457 aa 49.6 kDa	No	1
TMPRSS5-002 ENSP00000441104 ENST00000545579	F5GX83 [Direct mapping] Transmembrane protease serine 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	448 aa 48.7 kDa	No	1
TMPRSS5-003 ENSP00000445528 ENST00000538955	F5H2M3 [Direct mapping] Transmembrane protease serine 5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	413 aa 44.7 kDa	No	0
TMPRSS5-004 ENSP00000437761 ENST00000540540	G5EA43 [Direct mapping] Transmembrane protease serine 5; Transmembrane protease, serine 5 (Spinesin), isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	198 aa 21.6 kDa	No	0
TMPRSS5-005 ENSP00000445930 ENST00000544476	F5H0U3 [Direct mapping] Transmembrane protease serine 5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	344 aa 37.4 kDa	Yes	0
TMPRSS5-006 ENSP00000437937 ENST00000536856	G5EA47 [Direct mapping] Transmembrane protease serine 5; Transmembrane protease, serine 5 (Spinesin), isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	147 aa 16.2 kDa	No	0
TMPRSS5-007 ENSP00000440783 ENST00000544634	F5GYA3 [Direct mapping] Transmembrane protease serine 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	388 aa 42.3 kDa	No	1
TMPRSS5-010 ENSP00000445502 ENST00000538770	A0A0G2JKU3 [Direct mapping] Transmembrane protease serine 5 Show all	Predicted intracellular proteins Show all		10 aa 1.2 kDa	No	0
TMPRSS5-011 ENSP00000443681 ENST00000539732	F5H8D2 [Direct mapping] Transmembrane protease serine 5 Show all	Predicted intracellular proteins Show all		17 aa 2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.