Expression of PPIB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Peptidylprolyl isomerase B (cyclophilin B)

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012720	CAB011487

GENE INFORMATION
Gene name	PPIB (HGNC Symbol)
Synonyms	CYPB, OI9
Description	Peptidylprolyl isomerase B (cyclophilin B) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	64155812 - 64163205
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166794 (version 83.38)
Entrez gene	5479
UniProt	P23284 (UniProt - Evidence at protein level)
neXtProt	NX_P23284
Antibodypedia	PPIB antibodies

PROTEIN BROWSER

PPIB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPIB-001 ENSP00000300026 ENST00000300026	P23284 [Direct mapping] Peptidyl-prolyl cis-trans isomerase B Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005790 [smooth endoplasmic reticulum] GO:0005925 [focal adhesion] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0032403 [protein complex binding] GO:0032991 [macromolecular complex] GO:0034663 [endoplasmic reticulum chaperone complex] GO:0040018 [positive regulation of multicellular organism growth] GO:0042277 [peptide binding] GO:0042470 [melanosome] GO:0044794 [positive regulation by host of viral process] GO:0044822 [poly(A) RNA binding] GO:0044829 [positive regulation by host of viral genome replication] GO:0048471 [perinuclear region of cytoplasm] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0060348 [bone development] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] Show all	216 aa 23.7 kDa	Yes	0