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LDHC

GENERAL INFORMATION

Gene name

 LDHC

Gene description

 Lactate dehydrogenase C

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in seminiferous ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA045442
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 LDHC (HGNC Symbol)

Synonyms

 CT32

Description

 Lactate dehydrogenase C (HGNC Symbol)

Entrez gene summary

 Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 18412307 - 18452058

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166796 (version 83.38)

Entrez gene

 3948

UniProt

 P07864 (UniProt - Evidence at protein level)

neXtProt

 NX_P07864

Antibodypedia

 LDHC antibodies

PROTEIN BROWSER
LDHC-001
LDHC-002
LDHC-006
LDHC-007
LDHC-008
LDHC-009
LDHC-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LDHC-001
ENSP00000437783
ENST00000541669
P07864 [Direct mapping]
L-lactate dehydrogenase C chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005929 [cilium]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006754 [ATP biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019244 [lactate biosynthetic process from pyruvate]
GO:0019516 [lactate oxidation]
GO:0019752 [carboxylic acid metabolic process]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 332 aa
36.3 kDa 		No 0
LDHC-002
ENSP00000280704
ENST00000280704
P07864 [Direct mapping]
L-lactate dehydrogenase C chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 332 aa
36.3 kDa 		No 0
LDHC-006
ENSP00000439555
ENST00000536880
F5H245 [Direct mapping]
L-lactate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 318 aa
34.8 kDa 		No 0
LDHC-007
ENSP00000441478
ENST00000537486
F5GZ11 [Direct mapping]
L-lactate dehydrogenase C chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 167 aa
18.3 kDa 		No 0
LDHC-008
ENSP00000443414
ENST00000546146
F5H5G7 [Direct mapping]
L-lactate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 183 aa
20 kDa 		No 0
LDHC-009
ENSP00000439060
ENST00000544105
G3XAP5 [Direct mapping]
L-lactate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 241 aa
26.3 kDa 		No 0
LDHC-010
ENSP00000443997
ENST00000535809
F5H155 [Direct mapping]
L-lactate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 225 aa
24.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.