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Weak to moderate nuclear membranous or nuclear positivity was observed in most cancer tissues. Prostate cancers displayed weak to moderate cytoplasmic immunoreactivity, with a granular pattern. Lymphomas, carcinoids, gliomas, colorectal, testicular and stomach cancers were generally negative.
Most cancer tissues displayed moderate nuclear and cytoplasmic positivity. A few melanomas along with occasional adenocarcinomas of cervix and endometrial cancers were strongly stained.
GENE INFORMATION
Gene name
PLK1 (HGNC Symbol)
Synonyms
PLK
Description
Polo-like kinase 1 (HGNC Symbol)
Entrez gene summary
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000070 [mitotic sister chromatid segregation] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000278 [mitotic cell cycle] GO:0000281 [mitotic cytokinesis] GO:0000776 [kinetochore] GO:0000780 [condensed nuclear chromosome, centromeric region] GO:0000785 [chromatin] GO:0000795 [synaptonemal complex] GO:0000910 [cytokinesis] GO:0000922 [spindle pole] GO:0000942 [condensed nuclear chromosome outer kinetochore] GO:0001578 [microtubule bundle formation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0006468 [protein phosphorylation] GO:0006996 [organelle organization] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007091 [metaphase/anaphase transition of mitotic cell cycle] GO:0007092 [activation of APC-Cdc20 complex activity] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007264 [small GTPase mediated signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0010997 [anaphase-promoting complex binding] GO:0015630 [microtubule cytoskeleton] GO:0016301 [kinase activity] GO:0016321 [female meiosis chromosome segregation] GO:0016567 [protein ubiquitination] GO:0018105 [peptidyl-serine phosphorylation] GO:0019901 [protein kinase binding] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0030496 [midbody] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031572 [G2 DNA damage checkpoint] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043393 [regulation of protein binding] GO:0045143 [homologous chromosome segregation] GO:0045184 [establishment of protein localization] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045862 [positive regulation of proteolysis] GO:0051233 [spindle midzone] GO:0051297 [centrosome organization] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051443 [positive regulation of ubiquitin-protein transferase activity] GO:0051726 [regulation of cell cycle] GO:0070194 [synaptonemal complex disassembly] GO:0071168 [protein localization to chromatin] GO:1901673 [regulation of mitotic spindle assembly]