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CLPX

GENERAL INFORMATION

Gene name

 CLPX

Gene description

 Caseinolytic mitochondrial matrix peptidase chaperone subunit

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA040262
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CLPX

Synonyms

Description

 Caseinolytic mitochondrial matrix peptidase chaperone subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 65148219 - 65185342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166855 (version 83.38)

Entrez gene

 10845

UniProt

 O76031 (UniProt - Evidence at protein level)

neXtProt

 NX_O76031

Antibodypedia

 CLPX antibodies

PROTEIN BROWSER
CLPX-001
CLPX-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLPX-001
ENSP00000300107
ENST00000300107
O76031 [Direct mapping]
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
A0A024R5X7 [Target identity:100%; Query identity:100%]
ClpX caseinolytic peptidase X homolog (E. coli), isoform CRA_a
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004176 [ATP-dependent peptidase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0009368 [endopeptidase Clp complex]
GO:0009841 [mitochondrial endopeptidase Clp complex]
GO:0010952 [positive regulation of peptidase activity]
GO:0016504 [peptidase activator activity]
GO:0016887 [ATPase activity]
GO:0042645 [mitochondrial nucleoid]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
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 633 aa
69.2 kDa 		Yes 0
CLPX-005
ENSP00000452611
ENST00000559218
H0YK07 [Direct mapping]
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
Show all
 130 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.