Fields »
ABOUT
HELP
BLOG
GPR182

GENERAL INFORMATION

Gene name

 GPR182

Gene description

 G protein-coupled receptor 182

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen, testis)
GTEx:Tissue enhanced (spleen)
FANTOM5:Group enriched (spleen, testis, liver, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 High expression in endothelial cells and interclated discs in heart. Additional expression in sinusoids, spleen.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA027037
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, testis, liver, lymph node)

GENE INFORMATION

Gene name

 GPR182 (HGNC Symbol)

Synonyms

 ADMR, AM-R, G10D, hrhAMR

Description

 G protein-coupled receptor 182 (HGNC Symbol)

Entrez gene summary

 Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56994446 - 56998441

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166856 (version 83.38)

Entrez gene

 11318

UniProt

 O15218 (UniProt - Evidence at transcript level)

neXtProt

 NX_O15218

Antibodypedia

 GPR182 antibodies

PROTEIN BROWSER
GPR182-001
GPR182-002
GPR182-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR182-001
ENSP00000300098
ENST00000300098
O15218 [Direct mapping]
G-protein coupled receptor 182
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001605 [adrenomedullin receptor activity]
GO:0001666 [response to hypoxia]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035556 [intracellular signal transduction]
Show all
 404 aa
45.3 kDa 		No 7
GPR182-002
ENSP00000487111
ENST00000556850
A0A0D9SG31 [Direct mapping]
G-protein-coupled receptor 182
Show all
Predicted intracellular proteins
Show all
 55 aa
5.6 kDa 		No 0
GPR182-201
ENSP00000486086
ENST00000622922
Q7Z4H2 [Direct mapping]
G-protein-coupled receptor 182; HBcAg-binding protein
Show all
Predicted intracellular proteins
Show all
 196 aa
21.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.