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Most cancers exhibited moderate cytoplasmic and nuclear postiuvty. Additional membranous positivity was seen in renal, urothelial and pancreatic cancers. Rare cases of colorectal, breast, ovarian, cervical, endometrial, head and neck cancers showed strong positivity. Several hepatocellular carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
CHP2
Synonyms
Description
Calcineurin-like EF-hand protein 2 (HGNC Symbol)
Entrez gene summary
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
O43745 [Direct mapping] Calcineurin B homologous protein 2
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008284 [positive regulation of cell proliferation] GO:0010922 [positive regulation of phosphatase activity] GO:0015031 [protein transport] GO:0042307 [positive regulation of protein import into nucleus] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0071277 [cellular response to calcium ion]
