Expression of PATL1 in cancer - Summary

CANCER ATLAS

Gene description

Protein associated with topoisomerase II homolog 1 (yeast)

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039030

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most of the malignant cells showed weak to moderate cytoplasmic immunoreactivity. A few lung adenocarcinomas and prostate cancers were strongly stained. Several non-Hodgkins lymphomas and testicular cancers were negative.

GENE INFORMATION
Gene name	PATL1 (HGNC Symbol)
Synonyms	FLJ36874, Pat1b
Description	Protein associated with topoisomerase II homolog 1 (yeast) (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	59636716 - 59668980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166889 (version 83.38)
Entrez gene	219988
UniProt	Q86TB9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TB9
Antibodypedia	PATL1 antibodies

PROTEIN BROWSER

PATL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PATL1-001 ENSP00000300146 ENST00000300146	Q86TB9 [Direct mapping] Protein PAT1 homolog 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932 [cytoplasmic mRNA processing body] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0008266 [poly(U) RNA binding] GO:0010467 [gene expression] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0030014 [CCR4-NOT complex] GO:0033962 [cytoplasmic mRNA processing body assembly] GO:0034046 [poly(G) binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0044822 [poly(A) RNA binding] Show all	770 aa 86.8 kDa	No	0