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YWHAB

CANCER ATLAS

Gene description

 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA007925
HPA011212
CAB003759

GENE INFORMATION

Gene name

 YWHAB (HGNC Symbol)

Synonyms

 YWHAA

Description

 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 44885676 - 44908532

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166913 (version 83.38)

Entrez gene

 7529

UniProt

 P31946 (UniProt - Evidence at protein level)

neXtProt

 NX_P31946

Antibodypedia

 YWHAB antibodies

PROTEIN BROWSER
YWHAB-001
YWHAB-002
YWHAB-003
YWHAB-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
YWHAB-001
ENSP00000361930
ENST00000372839
P31946 [Direct mapping]
14-3-3 protein beta/alpha 14-3-3 protein beta/alpha, N-terminally processed
V9HWD6 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032403 [protein complex binding]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0035329 [hippo signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042470 [melanosome]
GO:0042826 [histone deacetylase binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0043234 [protein complex]
GO:0043488 [regulation of mRNA stability]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050815 [phosphoserine binding]
GO:0051219 [phosphoprotein binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051291 [protein heterooligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 246 aa
28.1 kDa 		No 0
YWHAB-002
ENSP00000300161
ENST00000353703
P31946 [Direct mapping]
14-3-3 protein beta/alpha 14-3-3 protein beta/alpha, N-terminally processed
V9HWD6 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0035329 [hippo signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042470 [melanosome]
GO:0042826 [histone deacetylase binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0043488 [regulation of mRNA stability]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050815 [phosphoserine binding]
GO:0051219 [phosphoprotein binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 246 aa
28.1 kDa 		No 0
YWHAB-003
ENSP00000394558
ENST00000445830
Q4VY20 [Direct mapping]
14-3-3 protein beta/alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019904 [protein domain specific binding]
Show all
 74 aa
8.4 kDa 		No 0
YWHAB-004
ENSP00000394729
ENST00000428262
Q4VY19 [Direct mapping]
14-3-3 protein beta/alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019904 [protein domain specific binding]
Show all
 100 aa
11.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.