Expression of DIS3L in cancer - Summary

CANCER ATLAS

Gene description

DIS3 like exosome 3'-5' exoribonuclease

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041805

GENE INFORMATION
Gene name	DIS3L (HGNC Symbol)
Synonyms	DIS3L1, FLJ38088, KIAA1955, MGC4562
Description	DIS3 like exosome 3'-5' exoribonuclease (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	66293217 - 66333898
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166938 (version 83.38)
Entrez gene	115752
UniProt	Q8TF46 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF46
Antibodypedia	DIS3L antibodies

PROTEIN BROWSER

DIS3L-001	DIS3L-004	DIS3L-005	DIS3L-006	DIS3L-007	DIS3L-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIS3L-001 ENSP00000321583 ENST00000319194	Q8TF46 [Direct mapping] DIS3-like exonuclease 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0000177 [cytoplasmic exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0016075 [rRNA catabolic process] GO:0019899 [enzyme binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	971 aa 111.1 kDa	No	0
DIS3L-004 ENSP00000321711 ENST00000319212	Q8TF46 [Direct mapping] DIS3-like exonuclease 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0000177 [cytoplasmic exosome (RNase complex)] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0016075 [rRNA catabolic process] GO:0019899 [enzyme binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	1054 aa 120.8 kDa	No	0
DIS3L-005 ENSP00000435792 ENST00000525134	E9PIL0 [Direct mapping] DIS3-like exonuclease 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0016075 [rRNA catabolic process] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	57 aa 6.9 kDa	No	0
DIS3L-006 ENSP00000436583 ENST00000532580	E9PI20 [Direct mapping] DIS3-like exonuclease 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0016075 [rRNA catabolic process] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	103 aa 12.4 kDa	No	0
DIS3L-007 ENSP00000436573 ENST00000530615	E9PI27 [Direct mapping] DIS3-like exonuclease 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0016075 [rRNA catabolic process] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	97 aa 11.6 kDa	No	0
DIS3L-009 ENSP00000432125 ENST00000525109	E9PS35 [Direct mapping] DIS3-like exonuclease 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0000176 [nuclear exosome (RNase complex)] GO:0006364 [rRNA processing] GO:0006402 [mRNA catabolic process] GO:0016075 [rRNA catabolic process] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	150 aa 17.4 kDa	No	0